Day: June 29, 2020
GULABO SITABO: Not the “Pehle Aap” Lucknow
How Depression Impacts the Immune system!!!
Major depression is a common and sometimes fatal disorder that has been identified by the World Health Organisation as a leading cause of disability worldwide. While antidepressants are undoubtedly effective treatments in about 70% of cases, a substantial proportion of patients remain partially or totally unresponsive to treatment. There is no simple explanation for treatment resistance but there is a possibility that the current antidepressants do not effectively target all of the pathological processes that are responsible for the major symptoms of depression. Thus there is an urgent need to broaden the targets upon which antidepressants are considered to act.
The concept of a disordered immune system playing a major role in the mental state can be traced back to antiquity. However, it is only in the past 30 years or so that clinical and experimental evidence has been obtained clearly demonstrating that aspects of both cellular and humoral immunity were dysfunctional in major depression. In the past 20 years, attention has been directed to the role of the immunomodulators and immunotransmitters, in particular the pro- and anti-inflammatory cytokines. Thus, Maes and coworkers reported that interleukin-6 (IL-6), a major proinflammatory cytokine, was increased in the blood of depressed patients.
It was also apparent that about 45% of patients being therapeutically treated with the proinflammatory cytokine interferon-alpha (IFN) developed major symptoms of depression that terminate when the cytokines was withdrawn. Recently a meta-analysis of 9 cytokines in major depression in which 24 studies were assessed concluded that only the basal levels of IL-6 and TNF were significantly raised. Such clinical observations suggest that proinflammatory cytokines contribute to the major symptoms of depression and now forms the basis of the inflammation, cytokine or inflammatory response hypothesis of depression.
When considering cause and effect, there are three possibilities that may explain the tie between depression and immune system:-
- Depression may weaken the immune system and cause increased susceptibility to illness.
- Major or long term illnesses may cause mood disorders such as depression.
- In some cases, illnesses or conditions may be caused by the same triggers as depression.
New research published has taken an exciting new approach, offering hope for those who currently don’t have effective treatments. It’s part of a growing evidence base that shows our immune system can directly affect our mood – and for some may even be a cause of their depression, rather than a consequence of it. Essentially, we are learning that our immune system can alter the workings of the brain. With around one-third of depressed patients showing consistently high levels of inflammation.
It comes down to the inflammation that is part of the immune’s system response to danger. It is a hugely complicated process that helps our body fight off hostile forces. But if the inflammation gets out of hand then it can cause damage to our body and brain.
Treating Depression and improving Health:-
- Get in a Routine:- If you are depressed, you are really in need to get in a routine. A routine will help to stay busy and keeping away the negative thoughts.
- Set goals:- When you’re depressed, you may feel like you can’t accomplish anything. That makes you feel worse about yourself. To push back, set daily goals for yourself.
- Exercise:- It temporarily boosts feel-good chemicals called endorphins. It may also have long-term benefits for people with depression.
- Eat Healthy:- There is no magic diet that fixes depression. It’s a good idea to watch what you eat, though. If depression tends to make you overeat, getting in control of your eating will help you feel better.
- Get Enough Sleep:- Depression can make it hard to get enough shut-eye and too little sleep can make depression worse.
These are the five things one need to give priority to, during depression. Other things a person could do to feel good is engaging in fun activities. They would do really good to the person who is depressed. Next thing we could do is to consult a psychologist.
Refrences:-

Make In India and Self-Reliant
Make in India is a iniciative started by the Union Government of India.This iniciative was started in September of 2014. 25 sectors were considered under this iniciative to manufacture most of the products in India.
The sole motive of this iniciative is to make India a global manufacturing hub. To invite foreign investors, Our government has allowed 100% foreign direct investment in key sectors of the economy.
25 sectors are-
1. Automobiles
2. Auto components
4. Biotechnology
3. Aviation
5. Chemicals
6. Construction
7. Defense manufacturing
8. Electrical machinery
9. Electronic system design and manufacturing
10. Food processing
11. IT and BPM
12. Leather
13. Media and entertainment
14. Mining
15.Oil and gas
16. Pharmaceuticals
17. Ports
18.Railways
19.Renewable energy
20.Roads and highways
21. Space
22.Textiles
23.Thermal power
24.Tourism & Hospitality
25. Wellness
Manufacturing sector contributes 16% to the GDP in India which is aimed to make 25% by 2022.
It is worth mentioning here that chinese manufacturing sector contributes 34% to the china’s GDP.
And in this way there would also be produced millions of job opportunities.
Recently honourable PM Modi announced ‘Aatmnirbhar’ package. here, self-reliance and make in india are co-related to each other.
The dream of being self reliant can’t be made true without active participation of make in india iniciative.
recent clashes are creating situation to put chinese product aside and go with make in india.Now the iron is hot, and there only need is to hit it with mass support.
Motivational Quotes – Reasons Why You Need to Read Them
Do you read motivational quotes? Most people read motivational quotes. Why they do that?
People wish to read quotes, because quotes are concise sentences, expressing wisdom, and awakening motivation, inspiration and happiness. Reading them resembles eating a bit of excellent chocolate or a slice of a delicious cake.
Why You Need to Read Motivational Quotes?
Motivational quotes motivate, inspire and encourage
Quotes have the power to motivate, inspire and encourage. Whenever you are feeling low, unhappy, or lacking motivation, read attentively a couple of quotes, and you’ll see how your mood and state of mind begin to enhance .
Motivational quotes energize and prompt you to require action
When you need a touch push and a few fuel to assist you’re taking action, motivational quotes are often of great help. At such times, it might be most helpful to read the words of individuals who achieved something in their life. Read their motivating words, and let these words sink into your mind.
Motivational quotes give insight and wisdom
Many quotes contain insight and wisdom condensed into a couple of words. If you read the quote a few of times, and specialize in the words, often, you’ll discover wisdom and insight which can assist you in your life.
Motivational quotes offer hope
Another benefit that you simply can gain by reading motivational quotes is hope. When during a difficult situation, once you don’t know what to try to to , or once you feel down, quotes are like rays of sunshine entering your life and driving away the darkness. I don’t mean that each quote would offer you hope, but quite few are really a beacon of sunshine .
They bring light and happiness into your day
A motivational quote has the power to awaken happiness and to embellish your day. It is an honest idea to read a few of within the morning, after awakening , and again, before your leave for work. Often, the words you read persist with you and affect how you think that that , act and react, for an extended time after reading them.
Motivational quotes teach
If you concentrate to the words, while reading a quote, you’ll gain good advice from it, which you’ll then implement in your life.
They open the mind to see life in a wider perspective
Quotes often open the eyes and therefore the mind to know truths and acknowledge belongings you otherwise would have missed. They allow you to see life from another, wider perspective, and during this sense, they expand the mind and therefore the awareness.
Motivational quotes are mood changers
Reading quotes can improve how you are feeling and alter your mood for the higher . It is like drinking something that uplifts your spirit. That is why it’s an honest idea to possess some good quotes handy, so you’ll read them whenever you would like to uplift your spirit.
They inspire to positive thinking and taking positive action
Good quotes make you feel positive, optimistic, energetic and optimistic, ready to set goals and take action. Their effect might continue for a touch while or longer. To set this attitude as habit, you would like to read quotes often and each day.
Reading motivational quotes does not require effort
It is actually fun and joy, doesn’t require any effort, and hardly takes quite a couple of moments.
I suggest you read a couple of quotes within the morning, after awakening , or simply before getting to work. You may also read them at night, before going to sleep. These aren’t the sole times suitable to read them. Any time of the day is suitable.
You may carry with you alittle notebook, where you’ll write the quotes you most like, and which have a robust positive effect on you.
You may also store quotes on your cell phone, where they can be always available to you when you want to read them.
Nowadays, there are numerous website with quotes on the web , and with a touch search, you’ll find many on every topic. You can easily find the words of famous and not so famous people, from past so far .
The Best Ways to Become Motivated Again
Every day we are faced with opportunities. Opportunities to change old habits, old fears, old mindsets that are harmful. Within the span of day , we’ve the prospect to awaken refreshed and begin anew. And sometimes, this suggests breaking down your actions step-by-step so as to rework yourself into who you would like to be.
For me, this entailed the concept of fighting my lack of motivation. Although most of the people believe motivation is that the opposite of procrastination, the 2 are in slightly different categories; procrastination is that the action of adjourning something until the top of its deadline, while motivation is that the reason behind one’s actions.
Like many of us within the world, I personally struggle with lack of motivation. After taking a while to look within myself, I even have discovered the essential ways to kick my mind back to gear. I not only found the way to stop procrastinating, but to also have a positive outlook so that the reasons for my actions would be encouraging and progressive.
- Morning Actions Are Key
When I used to wake up in the morning, I went into autopilot mode. I quickly learned that my version of autopilot only included the actions I wanted to try to to , not what I needed to try to to . But the core of my issue was that I never really knew what I needed to do.
To make every day count as something productive, I make small choices that make an outsized impact.
Instead of hitting the snooze button first thing in the morning, I wake up at the initial chime of my alarm clock.
Instead of scrolling through social media on my phone or answering emails, I make my bed or cook breakfast.
When I have a way of accomplishment at the beginning of my day, even with small actions, I start momentum for accomplishing tasks for the remainder of the day.
- Do Anything to Keep Moving
Sometimes, my mind turns simple daily tasks into large, insurmountable projects. It can feel crippling just to think about what I have to do next. I would often lay in bed within the morning, stare at the ceiling, and just ponder all that I had to try to to for the day. It became incredibly overwhelming, and more often than not, I would not complete most of my tasks.
To regain motivation during this way, I break down my day into smaller pieces. When I focus on one task at a time and set a reasonable time limit for myself to accomplish each task, I’m not worried about the future or regretting past actions. I allow myself to stay in the present.
Of course, I realize i’ll have some off days where everything looks like a struggle. If this is the case, I tell myself to just do something small. Just get out of bed and put your feet on the floor. Just check the first three emails in your inbox.
Once I became victorious with the actions that seemed insignificant, I felt much more empowered to take on important tasks.
- Believe in Yourself
It’s easy to get in the cycle of self-doubt. I will be the primary to mention that i’m my worst critic. However, I will never have a reason to do something if I don’t truly believe that I can succeed. Confidence are often attained even through the foremost minor actions.
Look within the mirror and tell yourself, I can do it!
Stand or sit up straight.
Get dressed up for the occasion.
When I took these small steps to spice up my confidence, I renewed my inner strength. I knew i used to be perfectly capable of handling anything to return my way.
- Create a Positive Environment
Achieving my goals came a lot easier to me when I surrounded myself with the right people. Sure, i’m capable of proving naysayers wrong, but the trend of regaining my motivation only came once I placed myself during a positive environment. I consistently had people lifting me up rather than tearing me down, which made me feel unstoppable.
Environment goes beyond a network of individuals , though. I also give myself a pleasing atmosphere to figure in. My desk is neat, my papers are organized, and that i have a routine I follow within my workspace in order that I don’t become mentally cluttered.
I also add comforts like my favorite color around my work area, pictures of friends and family on my desk, and posters or knick knacks that make me smile
- Remember Your Short and Long-Term Reasons
Why are you starting this project? Are you contributing to your overall career? Are you working toward a selected degree or credential?
Whenever I’m feeling stuck about what i want to try to to , I remind myself of what I’m getting to gain from the experience. Most importantly, I don’t allow myself to settle for losses.
However, if I’m in the process of working toward a goal and I feel unsatisfied or I believe my goal needs to be adapted, I’ll grant myself the ability to change along the way. This takes discernment of when to be creative and flexible, but really, it’s all about knowing what you are and are not willing to compromise.
- Pause and Recharge
There’s nothing wrong with taking breaks, especially if the action is overwhelming. If you’ve got been taking the means , remember to hamper every now then .
As a person’s being, it’s essential for you to require time for yourself within the sort of self-care. Personally, I’ve noticed that once I take a minimum of an hour every day for myself, I become even more prepared to require on whatever tasks are before me. The goal here is to not be so burned out that you don’t even try again – it’s only that much harder to bounce back.


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