Engineers for developing Biological Systems

Engineering has already shaped the view of systems biology and its application to fundamental knowledge, bioremediation, and human health. Already, systems bioengineering has begun to establish a core set of principles for problem-solving that fuses experiments and computation. Some of which are discussed below-

Engineering of artificial gene networks-  Significant efforts were recently undertaken in the design of artificial genetic networks in prokaryotic and eukaryotic systems. Here, different genetic elements or parts are ultimately rationally combined to devices to realize specific cellular behaviors that have frequently analogies to elements from electric circuits such as switches and oscillators.

Networks for intercellular communications-  Creating macroscopically observable artificial functional behaviour in a cell population requires synchronization. Such synchronization can be enforced by adding chemical inducers or by letting the cells themselves produce a signal in response to a change in a culture property. One example for such a property is cell density which can be communicated by quorum sensing, for example via the luxR/luxI system of Vibrio fischeri or artificially engineered systems

Engineering of systems- Engineering biology is a very young discipline that follows a powerful technological vision. However, there are no examples available where the whole approach has been implemented. Still, in some cases, specific aspects of biology have been of critical importance. The design of an E.coli capable of image processing, refactoring of the phage T7, the design of novel polyketide antibiotics and the manufacturing of precursors for the anti-malaria drug artemisinin.

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