Regeneration is the process of renewal, restoration and growth that, makes genomes, cells, organisms. It is basically the process in which an organism regrows its lost parts, so that original function is restored. This ability to regenerate differs in different groups. For example: lizards who lose all or part of their tails can grow new ones, Sharks continually replace lost teeth, spiders can regrow missing legs or parts of legs etc.
It is one benefit or advantage for animals in which they can immediately regrow the parts of body which may be involved in locomotion, reproduction which are one of the most important processes in the life.
On the other hand, Regenerative therapy or regenerative medicine can be defined as the process of replacing or regenerating human cells, tissues, or organs to restore or establish normal function. Regenerative Medicine refers to a group of biomedical approaches to clinical therapies that may involve the use of stem cells. Regenerative therapy may enable scientists to grow tissues and organs in the laboratory or in in-vitro conditions and safely implant them when the body is unable to heal itself. Also rather than a simple scar as a result of injury can regenerate, there are some human organs and tissues that can regenerate. These include liver, fingertips and endometrium. The cartilage cells divides more as we age.
Veterinary medicine have been integral part and has been associated to the development of stem cell therapies. The large experimental animal models have always contributed large to the development of stem cell therapies and refinement of modern hematopoietic stem cell transplantation were noted nearly 5 decades ago. To restore the damaged cells, tissues, organs it is critical to understand the development mental process of specific tissues and them reproduce it. Stem cells play essential roles in organ developmental and tissue repair. Stem cells have always contributed to these experiments and are one of the most used techniques which are used in the field of developmental biology basically in regeneration of different important parts of our body like the bone regeneration or cartilage regeneration and may more. The embryonic stem cells differentiate into multipoint stem cells, including epithelial, mesenchymal, and other tissue- specific stem cells. Stem cells are actually the mesenchymal cell which are pluripotent in nature which means the cells basically are self replicating and are derived from human embryos or human fatal tissue and are known to develop tissues of the three primmer germ layers. Stem cells are present in our body in different types of tissues. A person’s body contains stem cells throughout their life and the body uses them when it needs them. Some parts of body has a regular presence and use stem cells like the bone marrow, dental pulp, adipose tissue, dermis, umbilical cord and the gut, in which the stem cells regularly divide to produce new body tissues for maintenance and repair. Developmental processes are initiated by interaction between these stem cells, resulting in the formation of highly specialised functional tissues and organs. The role of animal models or animal regeneration has a very important role to play in this human regenerative therapy. Right now also the researches on animal regeneration is carried out and works shows some human regenerative therapies can be carried out using them. Researches and advancements in this field which the stem cells and regenerative medicine continue to expand the knowledge of the basic biology and clinical applications of stem cells. Many of the pioneering developments in these fields of stem cells research have been achieved through collaborations of veterinary and human scientists. This review aims to provide an overview of the contribution of the large animal veterinary models in advancing stem cell therapies for both human and clinical veterinary patients may play in the future evolution of stem cell therapies for both human and animal patients will be explored.
Regenerative medicine implies replacement or regeneration of human cells, tissue or organs, to restore or establish normal function. Regenerative medicine or the human regenerative therapy is one of the major advancements in recent years which works on the principles of stem cell technology and tissue engineering in order to replace or regenerate human tissues and organs and restore their functions. This therapy has helped in the field as it can be used in the treatment of acute injuries, chronic diseases and congenital malfunctions. Many advances in regenerative medicine, including the basic and translational researches, have been developed and tested in experimental animals; pigs have played an important role in various aspects of this work. The value of pigs as a model species is being enhanced by the generation of specially enabling more sophisticated research to be performed and thus accelerating the clinical applications of regenerative medicine.