Persecution of Muslims is the religious and political persecution that is inflicted upon followers of the Islamic faith and/or those with a Muslim identity. This page lists incidents in which Muslim populations have been targeted for persecution by non-Muslim groups throughout the history of Islam, a history that coincides with medieval and modern history.

In the early days of Islam in Mecca, the new Muslims were often subjected to abuse and persecution by the pagan Meccans (often called Mushrikin: the unbelievers or the polytheists). In the contemporary period, Muslims face religious restrictions in some countries. Various incidents of Islamophobia have also occurred, such as the Christchurch mosque shootings, the Afghanistan conflict (1978–present), the Kashmir conflict, the Xinjiang Ethnic cleansing and the mass imprisonment of people in re-education camps, the West Bank annexation in Palestine, and many more incidents.

The ongoing Rohingya genocide has resulted in over 25,000 deaths from 2016 to the present, 700,000+ refugees being sent abroad since 2017, gang rapes and other acts of sexual violence which are mostly committed against Rohingya women and girls, mostly by Rakhine’s Buddhists and Burmese soldiers, the burning of Rohingya homes and mosques, as well as many other human rights violations.

The ongoing Uyghur genocide has led to more than one million Muslims (the majority of them are Uyghurs) being held in secret detention camps without any legal process, with birth rates plummeting in Xinjiang, falling by nearly 24% in 2019 alone compared to just 4.2% in the rest of China.