Category: Education

Education is the process of facilitating learning, or the acquisition of knowledge, skills, values, morals, beliefs, and habits.

Disrupt, Divide, and Develop

The Effects of Covid-19 on Education

The pervasive nature of the Covid-19 pandemic has created one of the largest disruptions of education in human history, countervailing all efforts to provide education for all children. It caused unprecedented changes and continues to change numerous aspects of education that we took for granted. In March 2020, schools around India began closing to avoid the spread of Covid-19. These sudden closures led to confusion and uncertainty amongst students, especially those who were appearing for their board exams. For other students, these abrupt closures brought about a perplexing break from school. These ostensibly temporary closures were made permanent once the nationwide lockdown was effectuated and students were separated from their schools.

According to data by UNICEF and UNESCO, more than 1 billion children were at risk of falling behind due to school closures during the pandemic. Schools for more than 168 million children globally have been completely closed for almost an entire year. Around 214 million children globally, which is equivalent to 1 in 7 children, have missed more than three-quarters of their in-person learning. Furthermore, more than 888 million children worldwide continue to face disruptions to their education due to full and partial school closures. 

In India, the closure of 1.5 million schools in 2020 impacted 247 million children enrolled in elementary and secondary schools. In early March 2021, only eight States and Union Territories had reopened classes 1 to 12; 11 had reopened classes 6-12 and 15 had reopened classes 9-12. However, the ongoing second wave has caused the complete closure of schools yet again, as well as either the cancellation or postponement of board exams, competitive exams, and entrance exams. 

We began a new academic year like never before – from our homes. To continue the process of education, schools were compelled to adapt, adopt, and evolve. The biggest change has been the abandonment of traditional notions of schooling and the shift to online learning and teaching. Teachers have had to adapt to teaching online, a complete shift for those who’ve had many years of traditional classroom teaching experience. The fun and exciting trip to school has been diminished to clicking a link to join our classes. Interactive classes have become eerily similar to videos on our laptop or phone screen with a tincture of interaction arising when teachers ask us whether we’re present. The extreme sport of completing notes just before the teacher calls out our names has become the tedious process of scanning our notes and sending them as a pdf. Eating with our friends in the school canteen has been replaced with us eating alone during classes. Our classmates have become little rectangles on our screens. Outdoor sports have disappeared from the list of extracurriculars that we did in school. The end of school or college life is marked by video calls instead of grand graduation ceremonies. A lot has changed. 

These changes have led to some pernicious problems. The blurring of lines between school and home has led to students feeling overworked. This holds true for teachers too as they answer questions, clear doubts, and create lesson plans at all hours of the day. Students often have to study and sleep in the same rooms now. According to scientific studies, this often leads to a decrease in productivity and concentration. Students, especially younger ones, are easily distracted during online classes, despite attempts to marshal concentration and focus, as a classroom atmosphere is non-existent. Teachers are unable to pick up cues such as body language and facial expressions, making it challenging to connect with and understand their students. Problems such as eye strain and headaches are more common now due to the drastic and unavoidable increase in screen time for students. Online classes are often disrupted by copious internet problems, power cuts, background noise, and vexing software problems. All forms of practical education have been eliminated. A lack of clarity on important events such as board exam and entrance exam dates has led to the upheaval of students’ plans that were formulated before the pandemic began, fueling a rise in students’ anxiety and uncertainty.  

Covid-19 has also been a catalyst to the widening of socio-economic gaps in society on numerous fronts. While the virus cossets no one, the fact that it has disproportionately affected students belonging to less affluent households, especially those in rural India, is indubitable. Undoubtedly, access to the internet and an appropriate device are the lifelines of online education. 

A UNICEF report from August 2020 highlighted that only 24% of Indian households have access to the internet. While television and radio were purported as an alternative, there is no substitute for an actual teacher. A more recent survey conducted by Learning Spiral in February 2021 revealed that more than 50% of Indian students in rural and urban areas don’t have access to the internet. Moreover, only 47% of the households that have access to the internet own a device that can access the internet. It also revealed that, while 27% of all Indian households have access to the internet, only 28% of those are in rural India, even though rural India comprises of nearly 71% of India’s households.

Families in rural India are plagued with other impediments to online education –  insufficient or no smartphones, having to borrow smartphones (and therefore may not get them at the time needed), not having enough money to buy an appropriate internet package, and patchy connectivity even if they have internet access. The severity of these problems is incalculable and more prevalent than in urban households.   

Assuming that the problems stop here would be specious. The closure of schools has obstructed the “Mid Day Meal Scheme”. India has about 120 million children enrolled in the scheme in over 1.26 million schools across the country. However, due to the disruptions caused by Covid-19, many States and Union Territories have been forced to stop this initiative, depriving children of their basic nutritional needs. This scheme also serves as a huge incentive for children to attend school. Therefore, its removal may negatively impact both their health and their education. Furthermore, incidents of domestic abuse and child labour have drastically increased as students can no longer be protected by going to school. 

The Covid-19 pandemic has been atrocious but there has been a silver lining. The pandemic has led to an “academic revolution” that, unfortunately worsened certain differences in our society, but has also alleviated certain differences. 

Even before Covid-19, there was high growth in and adoption of education technology. Projections have shown that the overall market for online education may be valued at $350 Billion by 2025. There has been a significant surge in the usage of language apps, virtual tutoring, video conferencing tools, online learning software, etc. This is not only providing alternative paths for education but it is also future-proofing education. Through programs such as Coursera and edX, students can attend classes that they normally wouldn’t have had access to. India is considered the largest marketplace for Massive Open Online Courses (MOOCs) after the USA.

In certain aspects, online learning has made school more inclusive and obviated numerous hindrances to education. The use of videos in class greatly benefits visual learners. The use of tools such as online polling and chats have improved the class participation of those who otherwise may have hesitated to speak up. Notes, videos, and other study material that are sent to students can be reviewed anytime so the pressure on students to complete their work “before the bell” has been reduced. Furthermore, differently-abled students who found it difficult to attend school in-person can now attend classes with their friends from their homes. 

As students are attending classes from their homes, commuting to school no longer blocks their schedules. This gives them more time for extracurriculars such as internships, online courses, and online competitions. It also allows them more time to do the things they enjoy such as singing, cooking, writing, and painting. Students are also honing their online collaborative skills and improving their digital literacy, this will immensely benefit them in the future as the entire world shifts online.    

Hopefully, the move to online learning creates a new, permanent, and more effective method of educating students. While this “new normal” has had certain benefits, we must remember the value of education for all and prudentially strive to shrink the divide caused by this unavoidable transition to online learning.     

Bioweapons

War have been a part of human history since the beginning of time. However, the agents used to carry out warfare have changed and evolved just like humans did over time. First people use to hurt each other with their bare hands and sharp nails or throw stones or sticks at each other. Then someone thought, lets join the stone and stick, which led to the development of spheres and other things specially designed to kill. With the discovery of fire came a new way to cause mass destruction over a large scale. As science evolved, so did the weapons used in wars. From swords, crossbows and canons to guns, bombs, and tanks. But then came the era of nuclear warfare, things so powerful that it could destroy the entire world as we know it. However, an agent of war many people don’t know about and whose use has increased with the advancements of biotechnology and microbiology are bioweapons. Bioterrorism technically is defined as the violent use (by a person or group of individuals) of biological substance or toxins to injure. For example, this covid-19 pandemic which could be a form of bioterrorism, killing millions. But lets start from the first advent of the use of bioweapons.

Throughout human history, bioterrorism has been an issue. The Assyrians poisoned their enemies’ wells with ergot, a toxin-producing fungus typically found in Rye. This is one of the first stories of the use of bioterrorism and goes back to the 600 BC. In a more recently published account, Pizarro delivered the native Indians clothing tainted with smallpox in the 1500s when he conquered South America. Another similar report claims that Britain may have utilised diseases to undermine its adversaries during North American colonisation. The country could intentionally have sent Native Americans blankets tainted with pox. Bioweapons spread fast and cause mass destruction. The Convention against biologic weapons, which forbids the manufacturing, development, stockpiling and use of biological weapons was signed by 103 states under the guidance of the United Nations in 1972. Its however, well established that even superpowers of this world are not ready for an attack or outbreak of a bioweapon like smallpox and ebola. The high fatality rate among infected people is attributed to the possibility of aerosol transmission and the relative simplicity of large-scale manufacturing. Anthrax and especially smallpox are regarded the most significant threats of bioterrorism.

During world war 2 extensive research was carried out and many bioweapons were stockpiled by various countries from both the allied and axis powers. In an attack performed by religious-cult Aum Shinrikyo in a Tokyo metro station in 1995 using sarin, a chemical affecting the nervous system, resulted in the revelation of the risk of bioterrorism. Pathogens can also be engineered in the lab to give antibiotic resistance and higher virulence factor for the use of bioweapons. But science can also be used to create defences against these pathogens. Vaccination therapies, genome sequencing of the organism and drug designing are just among the wide biodefense’s science has to offer.

Some of common bioweapons used are:

  • Anthrax: Highly infectious and deadly, caused by bacterium bacillus anthrax. Having an incubation period of 7 days it can affect animals, humans, and children. It can be clinical diagnosed as either cutaneous, gastrointestinal, or inhaled. Its however, difficult to diagnose as it mimics the symptoms of a common cold.
  • Smallpox: Highly contagious and deadly, smallpox has been eradicated from the world thanks to vaccines, however smallpox vials had been stored in US and Russia in the name of research and these vials have been reportedly stolen, leaving the entire world population which is mostly not vaccinated against smallpox due to its eradication, at a high risk. If there is a smallpox attack, there aren’t enough vaccines for most of the people.
  • Cholera: Bacterium caused disease which was endemic in many parts of the world a few decades ago, cholera is transmitted through water ways and can be used as a bioweapon.
  • Salmonella: It’s a species of bacterium which infects the food you eat. Mixed with any food, it could cause gastrointestinal problems. However, it’s not considered that dangerous as food can be removed from the market.
  • Botulism: Produced by clostridium botulism its one of the most fatal toxins in the world. It can be inhaled or be present in your food, mostly canned food. Causing paralysis, vision problems suffocation within days or hours depending on the amount consumed, this bioweapon is highly dangerous and just need a few micrograms to kill millions. Once a person inhales it, its most certain death because an antidote does not exist for the toxin.
  • Ebola: Causing death in 90% of the people infected, Ebola is a much-feared virus that can be used as a bioweapon.
  • Ricin: Another toxin which is famous for being the bioweapon in the “umbrella murder case” its found in castor beans.

Although diseases are genetically modifiable, there is no evidence of virulence increase and the ability to promote an epidemic. This is no guarantee, however, that this risk is gone from the world. Because bioterrorism is a problem of global security, intelligence agencies have the responsibility to verify their actual potential and expansion. Some military specialists think Iraq still has an active bio war programme. A few years ago, a rare disease triggered an epidemic in Iraqi wheat fields, suspected of escaping a pathogenic infection from bioterrorism investigative facilities. Intelligence, constant monitoring, early warning systems, information sharing between agencies and cooperation should be part of any preventive programme in bioterrorism. Legislation should be in place that allows the government to apply quarantines to suspected people or items infected with infection, confiscate property and use hospitals for the benefit of the public. Finally, nobody should presume that biology and biotechnology science are always used for good. Biotechnology could be used in states that sponsor terrorism in the development of mass destruction pathogens and pests. Recent events have made us conscious of the worldwide community, and local events often have an impact around the world. It is crucial that one must be aware that science with all its benefit can also cause bioterrorism.

Plant tissue culture and related opportunities

Introduction

Plant tissue culture (PTC) is a bunch of procedures for the aseptic culture of cells, tissues, organs and their parts under characterized physical and chemical conditions in-vitro and controlled climate. It likewise investigates conditions that advance cell division and hereditary re-programming in-vitro conditions and it is viewed as a significant instrument in both fundamental and applied examinations, just as in business application. It is a territory of applied science that gives a wide stage to the aseptic culture of cells, tissues, organs, and their segments under characterized substance and physical in-vitro conditions. This science follows an essential idea where the plant body or organ or any tissue can be dismembered into more modest parts called “explants” and any explants can be additionally formed into an entire plant. Plant recovery shapes the premise of in-vitro engendering. There are different ideas and strategies that are as often as possible rehearsed in plant tissue culture science. In current biotechnology, the greater part of the ideas and procedures manage the hereditary investigation of plants. In present day plant biotechnology, the quality of interest is removed from the genome with the assistance of a limitation catalyst. The quantity of plants developing wild increasingly more decreases, as a result of the aimless assortment, in this manner numerous species are vanishing quick and those current are frequently unusable because of unequivocally dirtied regions. In such circumstance the presentation of types specifically compelling in development and training, can be entirely beneficial and the mechanical control on their spread can ensure a consistent biomass accessibility. These cycles incorporate different fundamental ideas and procedures that lead to the progressive improvement of callus lastly foundation of the ideal full cell line of the plant, which could be probed again for different exploration purposes.

General steps of plant tissue culture

1. Micropropagation 

Micropropagation begins with the choice of plant tissues from a solid, vivacious mother plant. Any piece of the plant can be utilized as explant. 

2. Preparation of donor plant

Any plant tissue can be presented in-vitro. To improve the likelihood of achievement, the mother plant should be ex-vitro developed under ideal conditions to limit defilement in the in vitro culture. 

3. Initiation stage 

In this stage an explant is surface sanitized and moved into supplement medium. For the most part, the joined utilization of bactericide and fungicide items is recommended. The determination of items relies upon the kind of explant to be presented. The surface cleansing of explant in synthetic arrangements is a significant advance to eliminate foreign substances with insignificant harm to plant cells. The most regularly utilized disinfectants are sodium hypochlorite, calcium hypochlorite, ethanol and mercuric chloride (HgCl2). The way of life is hatched in development chamber either under light or dim conditions as per the technique for spread. 

4. Duplication stage 

The point of this stage is to build the quantity of propagules. The quantity of propagules is duplicated by rehashed subcultures until the ideal number of plants is achieved. 

5. Rooting stage 

The establishing stage may happen at the same time in a similar culture media utilized for increase of the explants. Nonetheless, now and again it is important to change media, including dietary adjustment and development controller arrangement to incite establishing and the improvement of solid root development. 

 6. Acclimatization Stage 

At this stage, the in-vitro plants are weaned and solidified. Solidifying is done step by step from high to low dampness and from low light power to high light force. The plants are then moved to a suitable substrate and continuously solidified under nursery. .

General requirements for plant tissue culture

  • Instruments. 
  1. Filter sterilization units. 
  2. Osmometer. 
  •  Transfer and Culture 
  1. Laminar flow cabinet, for all controls requiring sterility. 
  2. Culture room or incubator.
  3. Orbital shaker, for cell suspension. 
  4. Low-speed bench centrifuge, for example, the Hettich Universal. 38-, 50-, and 280~pm mesh hardened steel strainers. 
  • Media 

Numerous media details have been concocted to help the development of refined plant cells. The most generally utilized media, MS, was created by Murashige and Skoog, other media incorporate B5 

  • Ultrafiltration 

Media containing heat labile parts e.g., indole acidic corrosive, gibberellic corrosive, zeatin, glutamine or complex combination of sugars e.g., KMSP should be channel cleaned by pull of the medium through a 0.2~pm breadth pore size channel. On the off chance that agar media are required, they can be channel sanitized at double the last fixation, and blended in with an equivalent volume of autoclaved twofold quality agar that has been permitted to cool to about 60°C. 

  • Growth Regulators 
  1.  Water-solvent: ABA (abscisic acid), GA, (gibberellic acid). 
  2. Dil. HCl-solvent: BAP (benzyl amino purine), kinetin, zeatin. 
  3. Ethanol solvent: 2,4-D (2,4-dichlorophenoxy acidic corrosive), IAA (indole3-yl-acetic acid), NAA (a-naphthalene acetic acid).

Types of technique for culturing plant tissue culture

  • Callus culture: Callus culture might be characterized as creation and upkeep of a chaotic mass of proliferative cell from disconnected plant cell, by developing them on counterfeit supplement medium in glass vials under controlled aseptic conditions. 
  • Single cell culture: Single cell culture is a technique for developing disengaged single cell aseptically on supplement medium under controlled condition. 
  • Suspension culture: Suspension culture is a kind of culture where single cell or little totals of cell duplicate while suspended in fomented fluid medium. Suspension culture are utilized in enlistment of shoots, creation of optional metabolites, in vitro mutagenesis, choice of freaks and hereditary change considers. 
  • Embryo culture: Embryo culture might be characterized as aseptic detachment of undeveloped organism from the greater part of maternal tissue of develop seed and in vitro culture under aseptic and controlled state of being in glass vials containing supplement semisolid or fluid medium to develop straightforwardly into plantlet 
  • Anther culture: Androgenesis is the in vitro advancement of haploid plants starting from strong dust grains through a progression of cell division and separation. 
  • Pollen culture: Pollen culture is the in vitro method by which the dust grains are crushed from the unblemished anther and afterward refined on supplement medium where the microspores without delivering male gametes. 
  • Somatic Embryogenesis: Somatic embryogenesis is the cycle of a solitary or gathering of cells starting the improvement pathway that prompts reproducible recovery of non-zygotic incipient organisms fit for developing to shape total plants. 
  • Protoplast Culture: It is the way of life of disengaged protoplasts which are exposed plant cells encompassed by plasma layer which is possibly equipped for cell divider recovery, cell division, development and plant recovery on reasonable medium under aseptic condition 
  • Shoot tip and Meristem culture: The tips of shoot can be refined in vitro creating bunches of shoots from either axillary or unusual buds. This strategy can, be utilized for clonal spread. 
  • Explant Culture: There are assortment of types of seed plants viz., trees, spices, grasses, which show the essential morphological units i.e., root, stem and leaves. Parenchyma is the most adaptable of a wide range of tissues. They are equipped for division and development 

 Application 

  1. In a generally brief timeframe and space, countless plantlets can be delivered beginning from the single explants. 
  2. In the living plant the conduct of each piece of tissue is unequivocally impacted by correlative controls forced by the remainder of the plant by disengaging it in vitro, the idea of a portion of these correlative controls can be resolved. 
  3. The creation of precise of plants that produce especially great blossoms, organic products, or have other alluring attributes. 
  4. To rapidly deliver develop plants. 
  5. The creation of products of plants without seeds or fundamental pollinators to deliver seeds. 
  6. The recovery of entire plants from plant cells that have been hereditarily altered. 
  7. The creation of plants in sterile compartments that permits them to be moved with extraordinarily decreased odds of sending infections, irritations, and microorganisms. 
  8. The creation of plants from seeds that in any case have extremely low odds of developing and growing, i.e.: orchids and nepenthes. 
  9. Used to preserve uncommon or imperiled plant species. 
  10. A plant reproducer may utilize tissue culture to screen cells instead of plants for worthwhile characters, e.g., herbicide opposition/resistance. 
  11. Enormous scope development of plant cells in fluid culture inside bioreactors as a wellspring of auxiliary items, similar to recombinant proteins utilized as bio-drugs. 
  12. To cross indirectly related species by protoplast combination and recovery of the novel half and half. 
  13. To cross-fertilize indirectly related species and afterward tissue culture the subsequent undeveloped organism this would somehow typically pass on .

Opportunities. 

Plant cell cultures have become a significant device to plant researchers, cell cultures have stayed a significant tool in the investigation of plant science, and today in vitro culture methods are standard methodology in the vast majority of the plant science’s labs. Cell cultures will stay as a significant device in the investigation of morphogenesis. Sub-atomic, physiological, and biochemical examinations on physical embryogenesis and plant recovery cycles will keep helping the manner in which cells pick any morphogenetic pathway. Notwithstanding Arabidopsis model, the disconnection of new mutants from PTC will help in this assignment. Cell cultures have remained, and will proceed, a critical tool in the investigation of primary metabolism, e.g., the utilization of protoplasts and vacuoles for the investigation of the components of poisonousness of hefty metals, just as the creation of safe plants situated in PTC innovation. The advancement of restorative plant cell culture procedures has prompted the ID of complete pathways of alkaloid biosynthesis. Comparative data emerging from the utilization of cell cultures for atomic and biochemical examinations is creating research action on metabolic designing of plant secondary metabolite production. The support of this information goes past essential examination. Huge spread of plants speaks to now a financially compensating undertaking and this will increment in the next years by consolidating new plants into the market, basically intriguing plants with new bloom tones and scents. On account of the improvement of genomics, proteomics, and metabolomics, plant. biotechnology is testing new and energizing advances. These “omics” approaches, with no uncertainty, will quicken the disclosure, disconnection and portrayal of qualities giving new agronomic characteristics to crops. Effective hereditary designing projects will be centered in the improvement of new plant assortments with attributes that expansion the nature of the harvests to battle undernourishment and in this manner the increment in the yields without the utilization of synthetic compounds in the field will stay a significant assignment. The new plant assortments should likewise give an expansion access the utilization of the land for horticultural point by beating issues, for example, saltiness, dry season and desertification. PTC strategy will likewise permit the creation of roots for food in bioreactors, under controlled conditions. Innovations for cell culture in enormous volumes for the creation of fine synthetic substances in hereditarily changed cells refined ought to be set up. This method presents points of interest over their creation in field developed plants that ordinarily possess significant expansions of land. The utilization of in vitro strategies in undeveloped organism salvage during plant reproducing, to spare hazardous annihilation plants, and the development of germplasm banks to safeguard plants with important attributes will help the consistent need of hereditary improvement programs 

Conclusion  

Plant tissue culture have caused critical commitments to the development of agrarian sciences as of late and today. They comprise a basic device in current horticulture. The admittance to innovation is not, at this point the selective of developed nations thus it is fundamental that we as a whole perceive the possibilities and that we use the innovation in the entirety of its measurements. The advantages as of now have moved from being viewed as simply part of the farming creation. The plants and the beneficial frameworks dependent on current horticulture are rapidly turning out to be significant income workers, and yet: ensuring food security worldwide and giving a superior way of life for every last one of the occupants of the planet. The innovation has exhibited its value and is accessible, presently it’s our chance to utilize it on a large however responsibly.

Engaging activities for the lockdown period

The lockdown period bothers everyone especially when all the social gatherings and meet ups are halted. We get plenty of time in our hands. This is the time when we can learn new skills and brush up the old ones. So why not look out for some interesting and productive activities which can be carried out even during lockdown.

>Catch up with old friends

It’s a great time to catch up with all the friends and family members you haven’t talked in a while. Chat with them on video call, play online games or just plan an online get together.

>Read books

Treat yourself with a good book. Reading is not just a great past time but also a productive activity. Read to get inspired or simply to learn something new and advance your vocabulary. Look for some good and easily accessible e-books.

>Get an online internship

During the time of lockdown on-site jobs and opportunities might not be possible but a virtual internship might prove beneficial. Many companies, associations and organizations are providing online internships to individuals which can be done from home. Look for the best suited internship for yourself. This might later help in grabbing good job opportunities post lockdown.

>Learn to cook

Try cooking and let your friends and family taste it. Start with basic and easy-to-cook recipes. Reach out to family and friends for cooking hacks and tips or just surf online for your favourite recipe. Participate in online workshops for cooking to master the skill.

>Maintain your personal diary

Ever read ‘The Diary of a Young Girl’ which is a collection of diary entries of a young girl during the Nazi rule in Germany? If you wish to do something similar, this is the right time. We are experiencing a pandemic and what better than this can be the theme for your diary entries. Create time line of events, collect newspaper articles and picture. This can also act as a pandemic time capsule. One day, you’ll be able to narrate these stories to your children and grandchildren.

>Get hands on a new skill

This can prove to be the perfect time to grab a new skill. Explore your creative side. Try out drawing, sketching or painting. If interested in music, go on to learn singing or instruments. Dancing, photography and art are also fun to do and really engaging.

>Start your kitchen garden

If you are an expert gardener and love to grow plants, this is the ultimate opportunity for you. Kitchen gardening is one of the most popular activities done during lockdown. What can be better than eating what you grow?

>Create a YouTube channel

Since most of the entertainment these days is digital, YouTube is a platform for fresh content. Just like most of the celebrities, you too can begin a YouTube channel and start uploading your fun and engaging videos.

New Online Academic Year, New Hopes

The door to yet another online academic year is about to open, amidst the worsening pandemic crisis. Bored by their previous experiences, students hesitate to get underway their similar routes. Students were nearly getting a kick out of their shores of hopes, awaiting campus fullfilment. But their hopes were shattered by the second yet dangerous wave of coronavirus followed by deadly infections such as yellow, black and white fungus. People are getting used to this prolonged period of closures. Everything is getting shut down, so are people’s minds. 

As the situation shrouding us is getting worse, teachers are off to adopt the mandatory online mode of teaching once again. Educators and administrators are forced to make an effort out of the challenges offered by the crisis. After a year of suffocation, students and teachers are almost used to this online teaching mode. Even though everyone knows the truth that education through digital screens will not be as lively and joyous as education in classrooms, we are bound to find new possibilities from these limitations. This new academic year may also be an opportunity for us to evaluate, correct and update our minds and body. 

 Disadvantages of Online Classes 
Smartphone classrooms were devoid of actual attention and brightness, instead, it was stuffed with boredom, negligence, painful memories and dimmed hopes. Kindergartens missed their excitement of packing up bags, hanging newly bought water bottles and jumping into their school bus with an urge to mingle. The major loss was experienced by school and college students. Cancelled sports day and cultural fests, no shared lunches or canteen snatches, no farewells and tours, and massively increased screen time marked 2020-21 academic session. Smartphones and laptops became the backbone of education. Well, along with education, we should consider its addiction too. Watching countless movies or episodes and sleeping for hours became a “new normal” routine for students. The non-availability of gadgets, which was a serious issue last year, currently boosted. It is now normal for school students to keep their own smartphones or laptops. 

 Benefits of Online Classes 
Blended learning also includes some benefits such as reduced time and elimination of travel costs. Students can also achieve several internships and online courses easily. Benefiting from these would aid your career in future.One could also get easy attendance by sitting at the comfort of your homes. 

Ways to enhance online learning 
 • Learning empowered with Videos and Notes. 
 Giving essential notes along with videos would bring a versatile and convenient flare to education. They serve as go-to resources that can be viewed anytime from anywhere. 
• Virtual Study Trips 
 Virtual trips increase the interest in students and grab their attention. 
• Do not burden students with too many lectures and assignments. Divide lectures into small chunks. Give limited assignments so that they could put their efforts in it fully. 
• Make time for fun 
Engage students with interesting games and competitions. There are several platforms to do so. It’s all about engagement. 
• Reduce time 

Attending online class continuously for 6-8 hours is exhausting and harmful for health. Reducing time and creating more quality content is more helpful for both students and teachers. 
• Prevent cheating in exams and sharing of academic documents. 

Despite the challenges and flaws of last year’s online learning, we can expect this year to be a better, promising one. Have gotten ideas on enhancing your e-learning, lets hope students and teachers utilise the best of it.

Explained: Net Zero and India’s stand on it

Lately, in April 2021, the US conducted a virtual summit on climate change with 40 world leaders to take bold pledges and chalk out prominent decisions on climate change. The summit has committed to achieving the Net-Zero target by 2050.

What is the Net Zero target?


Net Zero also referred to as carbon-neutrality is that situation where the entire man-made greenhouse gas from the atmosphere has been removed.

The summit held in April decided to achieve a balance on the emission of greenhouse gases and the removal of the same from the atmosphere.
Canada, South Korea, Japan, and Germany have committed to attaining a net-zero future.
India is the third-largest emitter of carbon after the US and China. And India plays a major role in global climate actions.

We all know that there has been a continuous rise in greenhouse gas emissions from industries, transportation, and livestock, resulting in global warming and prominent changes in climate patterns.
These harmful gases trap the heat and don’t allow them to escape the earth, causing temperature rise. The continuous change in climate patterns are causing severe floods, droughts, cyclones, and whatnot thereby leading to mass destruction of lives and property.

“The global temperature rose a total of 4 to 7 degrees Celsius over about 5,000 years. In the past century alone, the temperature has climbed 0.7 degrees Celsius, roughly ten times faster than the average rate of ice-age-recovery warming” as observed by NASA World Observatory.
“Models predict that Earth will warm between 2 and 6 degrees Celsius in the next century”.

If the global temperature rose at this pace, it would prove catastrophic. So in 2015, the 21st meeting of the United Nations Climate change conference took place to collectively agree to limit carbon emission by 1.5 degrees Celsius.

How to achieve Net Zero target?


Thus, the countries jointly agreed to become carbon-neutral or Net Zero carbon emitter by 2050. In achieving so the countries would have to balance their carbon emissions by removing the carbon from the atmosphere.

The countries have to develop renewable energy resources instead of burning fossil fuels, replacing fuel-based vehicles with electric vehicles, developing efficient technologies, etc. Also, the energy, transportation, and manufacturing sectors need to adopt net-zero targets.

Plants and water bodies are great carbon sinks as they absorb carbon from the air. Hence, expanding more forest cover would eliminate the carbon content from the atmosphere.
There are other technological techniques for containing atmospheric carbon.
Carbon sinks are a man-made reservoir where carbon-containing compounds are stored for an indefinite period for future usage, thereby decreasing the CO2 concentration from the atmosphere.

Measures adopted by countries:


Bhutan is the only country in the world that is “carbon negative” which means that it absorbs more carbon than it emits.
Countries like UK and France, have already enacted laws promising to achieve a net-zero emission by the middle of the century. China has promised to go net-zero by 2060.

India’s stand:


For India the scenario is different. India still has to reach the peak of emission, as for over next 2-3 decades the carbon emission would to grow because the country has to pull millions of people out of poverty.
Also, the carbon removal technologies are either unreliable or very expensive.
So, it’s not that India is straightaway striking out the carbon neutrality target by 2050, it’s that India at this point does not want to internationally announce any commitments.

Thus, the decision of attaining the Net Zero target is very arduous and challenging. The developed countries responsible for great carbon emission historically must take urgent steps and help developing nations with technology and capital to fulfill the cause.

CRISPR the genetic scissor: Alluring or repelling?

The marvels of human discovery has no bounds. From reaching the moon to creating vaccines, man has always been on the lookout for creating an impact, be it influential or destructive. CRISPR is one such discovery which can revolutionize treatment of diseases. When man landed on moon, people talked about how we may corrupt it. When he created vaccines, people talked about how it may kill instead of curing. Discoveries are followed by heavy criticism. Sometimes, these can be ignorant ramblings. Sometimes, a warning of the inevitable. So, when CRISPR was discovered, critics implied that it may lead to the extinction of an entire species! Is it a useless rambling or a warning?

What is CRISPR?

CRISPR is a gene editing technique which allows us to edit our very origin, the DNA. In simple words, just like using a CTRL C, CTRL V and DEL on our computers, CRISPR allows to us to delete defective gene, copy a good gene and allows us to paste it in place of the mutated gene. Instead of taking care of the aftermaths of a disease causing mutated gene, we now cut it altogether and thus eliminate the disease altogether. Indeed a genetic scissor.

The silver lining of all this is that, it is extremely efficient, fast and cost conservative. Yes, hearing about gene cutting and editing, you could’ve been convinced that it isn’t for the common man. But no, you are gravely mistaken. In fact the reason some people consider it a curse is because of its affordability and efficiency, which when misused, can cause some serious irrevocable damage to the chain of lives.

The science behind

If you do not want to get into the details, then you may very well skip this heading and move onto to the next. But let me tell you, devil’s in the details! Much like a coded computer program our genes are essentially coded patterns of chemicals: adenosine(A), cytosine(C), guanine(G) and thymine(T). Our DNA is a specific arrangement of 6 billion of these chemical building blocks. Just like how a single error in the computer program can disrupt its functionalities, a single error in arrangement of A,C,G,T results in genetic diseases. 1 error among 6 billion and everything breaks into chaos. Read more here.

For instance, lets consider sickle cell anemia where our body doesn’t have enough healthy red blood cells as some of the cells become ‘sickle’ shaped leading to shortage of blood flow. The sickle shape is occurs when A is replaced with T. Without CRISPR, a person suffering from sickle cell anemia has a 15% chance of curing it by bone marrow transplantation, a costly solution. With CRISPR, all we have to do is correct the error. Cut the additional T, prepare a healthy A, and insert it in the place of the second T. Voila, you are now free of sickle cell anemia with your pockets not emptied!

The ethical concerns

The major concern revolving around CRISPR is the aftermaths it may cause. While trying it rectify a genetic error, we may by mistake create a new one by cutting excessive DNA, or pasting a different one. An individual impaired with such unintended consequences of CRISPR, not only suffers himself, but can also pass it to his/her generations due to gene-drive. Gene drive is preferentially inherited by all offspring which in turn can pass it on to their offspring.

CRISPR is actively being used to modify genes of animals and insects. We can now design plants with higher yields and with higher nutritional content, animals which are susceptible to diseases, and even mosquitoes which are rendered sterile. This can lead to the extinction of the entire mosquito species. This can disrupt the entire food chain as a species whose food source was the extinct species, will now be endangered too, setting off a chain reaction.

Designer Babies?

With CRISPR science fiction can come to reality. CRISPR allows us to modify our genes. Genes are who we are. So it literally allows us to modify who we are! Genetically editing human embryo instead of kids or adults, can result in creating the ‘ideal’ baby. Genes which promote increased muscle strength, brain activity can be pasted which allows babies born to be more healthy and intelligent.

You know where this can lead to and the increased concern this can provide. With CRISPR additionally being cost effective, who is to say no to a healthier intelligent baby? This leads to unnatural selection, defying Darwin’s evolutionary natural selection model, producing a race of superhumans. Even though the CRISPR on human embryos is highly disallowed, some may try to misuse it, causing devastating effects.

Concluding remarks

The world is moving at an alarming pace. Who knew 20 years ago that you can communicate across seas with just one click on the phone. While as alarming as it maybe, it has also lifted people up, proving that advancements do more good than bad, forcing us to go with the flow. It is up to the ethics of humankind to keep the good-bad balance and make sure that advancements not only improve the lifestyles of humans, but also the compassion in our hearts, for we are nothing but borrowed fragments of compassion, left by our ancestors.

 

Compassion isn’t about giving solutions, it is about giving all the love you’ve got.

-Cheryl Strayed

Apoptosis- A potential target for cancer therapy

Introduction

The avoidance of apoptosis by cancer cells is a prominent characteristic of cancer. Since apoptosis inhibition is at the heart of tumour growth, the clearing of malignant cells and retaining a definite number of healthy cells involves tumour-cell death. Cellular death pathway targeting provides some possible therapeutic targets for all cancers. The most obvious strategy for cancer treatment is to concentrate on lesions, particularly apoptosis in tumour cells, which eliminate cell death.

Apoptosis is an essential component of normal development. For keeping normal physiological processes between cell proliferation and cell deaths, homeostatic balance is essential. Aberrant control of apoptotic mechanisms is one of the main characteristics of cancer growth and development. Apoptosis can be activated by triggering two different molecular pathways, a pathway of the extrinsic, a death receptor or a mitochondrial pathway, intrinsic pathway also called apoptotic cascade. Extrinsic pathways from outside the cells are activated by pro-apoptotic receptors, such as CD95 and TNF-related ligands inducing apoptosis (TRAIL) interacting with specialised cell surface death receptors. Mitochondrial (intrinsic) pathways induce the transcription of or the post-translational activation of BH3 proapoptotic B-cell leukaemia / lymphoma 2 (Bcl-2) family proteins from the inside of the cell, as a result of extreme cell pressure such as DNA or cytoskeleton damaging apoptotic protease-activating factor-1 (Apaf-1) and assemblies of Cytochrome c  activate caspase 9. This caspase activates the effector 3, 6 and 7 caspases, which perform apoptosis. Latest development of different therapeutic methods that interfere with apoptosis and are commonly used or studied for cancer treatment are becoming popular. It induces cancer cell death or enhances the response to certain cytotoxic medicines of cancer cells and CCs. Some of them are still in preclinical and clinical trials such as caspase activators, apoptosis modulators or agents targeting apoptosis-related proteins. Future methods for targeting apoptotic pathways in cancer patients with promising application are also seen.

Therapeutically inducing apoptosis strategies

The progressive pre-clinical or early clinical development of many therapeutic approaches inducing apoptosis are seen. The research processes two styles from a mechanical perspective of separate approach: (a) specifically separating tactics induce apoptosis, which is here called pro-apoptotic; and (b) survival-signalling techniques that modulate this to promote apoptosis, which is called permissive approach.

Proapoptotic approach:

Apoptin. A promising tumour killing technique

Apoptin (VP3) is a cell used when sparing normal cells and killing only tumour cells. The chicken anaemia virus is a source of 14,000 proteins. Latest evidence shows that this molecule induces apoptosis in which Caspases are included. Apoptin is very much shown, in vitro findings, that it is active against cancer cells without induction of natural toxicity Cells. The basic effect of it being this tumour killing only could be clarified by nuclear tumour cell location of the protein, activity requirement, whereas the protein in normal cells are Cytoplasm localised. In addition, apoptin is also active and potentially chemo resistant in genetically disrupted cells such as p53, Bcl-2 or tumour cells that express BCR-ABL. Apoptin is under progress in tumour cells in vivo in gene therapy strategies. Multiple injections of adenovirus into healthy rats or nude mouse have not been found toxic in preclinical studies. Furthermore, antitumor effects in the nude s.c. mouse were observed, hepatoma in human beings. These findings, however, remain preliminary and more preclinical work is needed with human cells to ensure safety and evaluate apoptin ‘s potential as an anti-cancer compound better.

Apoptosis was examined for the development and treatment of cancer by attempting to determine its function in chemotherapy cytotoxicity caused by agents. Cytotoxic agents frequently lead to apoptotic by only a fraction of the cells. A significant portion of cells must be recruited into apoptosis to allow maximum use of apoptosis as a mechanism for anti-neoplastic agent response. The only regularly used cytotoxic agents that have been shown to induce apoptosis in breast cancer cells are paclitaxel (Taxol ®). Another of such cytotoxic agents is cyclophosphamide, and furthermore cytosine arabinoside is also used. Quantitative measurements of apoptotic cells were performed by controlling the binding of the phosphatidylserine-binding protein (FITC)-labelled annexin V into cellular cells.

Inhibitor of apoptosis protein (IAP)

The genome of baculoviruses was the original founder of IAPs because of their capacity in infected host cells to inhibit apoptosis. Re-based on the survival and XIAP of recent attempts to use IAPs to obtain anti-cancer treatment. In vitro experiments showed that the anti-apoptotic function of the proteins was inhibited by caspases-3, -7, and -9. As these cases have shown to be important in vitro for chemical apoptosis aimed at its natural inhibitors, the IAPs have been identified as a possible means of increasing chemosensitivity. In fact, NSCLC cells inhibited up to 70 per cent of surviving mRNA expression with the use of the oligonucleotide 4003, resulting in etoposide sensitization of cancer cells. Additionally, the downregulation of XIAP in ovarian cancer cells with wild type p53 by adenoviral antisense expression has caused apoptosis. These promising findings have led to clinical trials using anti-sense IAPs being mapped. The IAPs’ function may be more complex than the in vitro data initially suggested. Indeed, in NSCLC patients c-IAP1, c-IAP2, and XIAP had no precedented response to chemotherapy responses, unlike most of the expected multiple in vitro trials. Moreover, in patients with non-Hodgkin’s lymphoma and AML, there were no variations in reaction to chemical therapy between survivin-positive and negative instances. Furthermore, XIAP expression was not associated and did not have any relation with the apoptotic index of NSCLC patients but was inversely related to tumour growth. In this group of patients, higher XIAP expression has been predictively converted into a considerably longer overall survival. In addition, the nuclear localisation of survivor has shown positive effects on prognosis in a recent study of gastric cancer patients. These findings verified that it may mean that limitless ODN survival inhibition may not be desirable both within the cytoplasm and the nucleus. It is possible that the IAPs are engaged in apoptosis inhibition by the blocking of caspase but also other essential functions including proliferating. These conflicting results can be clarified. In addition, the net effect of IAPs can depend on their interaction with the control molecules Smac / DIABLO, HtrA2 and Factor1 associated with XIAP, an antagonist of the XIAP apoptotic operation. Therefore, while it is potentially promising, additional functional research and IAP interactions are required to better utilise them as goals for anti-cancer therapy.

BH3 Mimetics

There is a common consensus that BH3-only proteins are essential for apoptosis, promulgating inherent and extrinsic pathways of cell death. Based on the blocks of the sequence homology called BH domains, proapoptotic members from the BCL-2 family may be further identified. Only one domain, in general called the α-helical BH3 region is available for all BH3 protein. This preserved BH3 domain played a key role in the treatment of cancer. Three BCL-2 protein subgroups: BH3 (BCL-2 homology 3), BCL-2, BCL-2-associated X-protein (BAX), and the BCL-2 antagonist-killer (BAK), interacting on one another on the mitochondrial membrane, activate the pathway. This is the basis of three distinct groups. BH3-only proteins have been shown to achieve two mechanisms by transmitting signals to induce apoptosis, and only BH3-proteins inducted by transcriptional or post-translational cytotoxic stress. The neutralisation of antiapoptotic BCL-2 proteins or direct activation of BAK and BAX 47 is a clear way to understand the previous mode of action, both structurally and functionally, and hence the goal for production of pharmaceuticals. By attaching its hydrophobic groove by adding four hydrophobe residues it antagonises the BCL-2 antiapoptotic protein family members. Members such as cell-death antagonist BCL-2 and NOxa bind to their anti-apoptotic brothers, while other proteins such as BIM, tBID and PUMA only neutralise other anti-apoptotic agents.

miRNA

The miRNAs (MiRNAs) is a small endogenous class of 18 to 25 nucleotide length non-encoding RNAs which modify gene expression by mRNA degradation or mRNA deletion. The mature-miRNA products are produced by sequential processing by the ribonucleases Drosha and Dicer1 from a longer primary miRNA (pri-miRNA) transcript. miRNAs are known to inhibit thousands of target genes, since the objective mRNA needs only partial complementarity. Thus, one miRNA can target at the same time to a complexity of mRNAs, and several miRNAs can control the expression of one particular mRNA. The alteration of miRNAs includes a varying variety of human diseases, including cancer, by natural mechanisms miRNA are involved in number of process, including cell growth, differentiating, proliferating, apoptosis, and stem cells self-renovation. The de-regulation of miRNA also induces apoptosis avoidance, involving tumorigenesis and pharmaceutical resistance. The functioning of aberrated miRNAs, which are closely linked to the apoptosis mechanism, will act as oncogenes (OncomiRs) or tumour suppressors (TSmiRs) during tumour induction and progression. Manipulation of the levels of miRNA expression affecting apoptosis genes and pathways may also be a clinical approach to develop successful cancer treatment. Furthermore, because cancer cells frequently display a distinct trend for miRNA expression, novel profiles of altered miRNA expression may be useful for tumour-diagnosed molecular biomarkers, disease-specific outcome predictions and tumour-aggression evaluations. Therefore, numerous anti-cancer therapies are being designed to recover miRNA behaviours and rebuild gene regulation networks or drug sensitivity. A number of miRNAs were associated with drug resistance, some of them linked to apoptosis. Deregulation of miR-214 is a frequent phenomenon in ovarian cancer in human beings and it has been shown that miR-214 mainly targets PTEN / Akt pathways and promotes cell survival and cisplatin tolerance. It’s also recognised that the let-7 miR family plays an essential part in a number of cellular functions including opioid sensitivity modulation. The miRNA let-7a, aimed at caspase-3 in human cancers, was over-expressed and demonstrated resistance to a range of drugs, including doxorubicin, paclitaxel and interferon-gamma, which are caspase-3-dependent. Let-7e was up-regulated with improved tolerance to doxorubicin in some ovary cancer cell lines. Conversely, let-7i has been documented as uncontrolled in ovarian cancer resistant to chemotherapy, and the reintroduction of let-7i could sensitise ovarian resistant cell line to platinum-based chemotherapy. The cause of apoptosis induced by the chemo preventive agent curcumin has been shown to be the downregulation of miR-185 in a non-small cell-lung cancer cell line which increased its direct target expression, Caspase-10. The effect on miRNA expression profiles was thus studied by anti-cancer drugs that modulate apoptosis cell proliferation and could help predict the resistance to apoptosis. This will help prevent needless morbidity and represent a new class of biomarks to allow customised care through the awareness of possible miRNAs involved in apoptosis resistance.

Blebbishield Formation

The development of blebbishields is one method used by cancer stem cells to resist apoptosis. The emergency system is enabled to rescue the stem cells in apoptotic cancer. The apoptotic blebs merge together into a formed sphere called blebbishields. Cells undergoing blebbishield development display visual symptoms of apoptosis, but the reaction is prevented and ends in cells living. Serpentine filopodia formation due to endocytosis are involved in blebbishield formation to avoid complete apoptotic reaction. Apoptosis normally results in secondary necrosis from a lack of ATP, blebbishields by activating glycolysis are able to prevent secondary necrosis. In order to ensure clinical effectiveness, cancer stem cells must be blocked to survive in parallel to treatments by apoptosis. A variety of possible candidates were identified including inhibitors of caspase, Smac mimetics and inhibitors of the translation at an internal ribosome entrance site (IRES). IRES translation is regulated by antiapoptotic proteins, such as cIAP-2, and XIAP. IRES translation facilitates survival by converting the cIAP-2, which enflames the mechanism and moves the antiapoptotic to the proapoptotic equilibrium towards antiapoptotic survival. Hemming IRES translation will prevent blebbishield formation from being started. N-Myc is an IRES translation goal intended to avoid the development of blebbishield.

Conclusion

Apoptotic approach to seeking alternative anti-cancer drugs is intriguing, since it is not unique to the form of cancer. In both the extrinsic and intrinsic pathways of cancer there are various mutations that cause cells to evade apoptosis, which is a distinctive characteristic of cancer. A more general cancer cure will also include the opportunity to target and activate apoptotic tract. Many compounds extracted from plants that are not toxic to healthy cells are particularly promising compounds to cause apoptosis.

Worst hit pandemics thorough ages

The novel Coronavirus has created a catastrophe in the entire world bringing it down to its knees with cases counting more than 16.7Cr, (as per the data provided by Wikipedia).

It’s not the first time that a pandemic has engulfed this large number of people from around the world. History has records of many deadly diseases creating havoc in the world.

Human civilizations have evolved and developed continually, causing population bursts. With no efficient knowledge of sanitation and hygiene, and poor health facilities people have unknowingly created fertile situations for the growth of these deadly infections.

The Centers for Disease Control and Prevention (CDC) has defined a pandemic as “an epidemic that has spread over several countries or even continents. Pandemics usually affect large segments of the population”.

Here’s a list of the worst hit pandemics through history.

Plague of Justinian, 541-542

Saint Sebastian pleads with Jesus for the life of a gravedigger afflicted by plague during the Plague of Justinian. (Josse Lieferinxe, c. 1497–1499)
Source pic- Wikipedia


The plague of Justinian was the worst pandemic recorded in history caused by the fatal bacterium called Yersinia pestis.
The plague was brought to Constantinople, the capital of the Byzantine Empire, in 541 CE from Egypt. During the time Egypt was paying a tribute to Emperor Justinian in grains.
The plague-laden fleas infected the rats eating grains.

This lethal disease spread like a forest fire across Europe, Asia, North Africa, and Arabia killing an estimated 30 to 50 million people, almost half of the world’s population.

Black Death (1347-1351)


This was a global bubonic plague that hit Europe in 1347-1351, astonishingly taking a toll of 200 million in just 4 years.
It was a type of plague that was spread via the bite of infected rat fleas.
This plague caused religious, socio-economic upheaval with a profound impact on European history. The bacterium that caused this was the same that brought the Plague of Justinian.

During this time the sailors that had came to Europe were required to stay on their ship for 30 days, which was known as “Trentino” in Venetian law. Later, the Venetians increased the forced isolation to 40 days or a “quarantino”. From here quarantine word was introduced which is now in great implementation.

The painting “Blessed Bernard Tolomei Interceding for the Cessation of the Plague in Siena” by the Italian artist Giuseppe Maria Crespi.
Source pic- Britannica

Spanish Flu 1918:

Source pic- World Health Organization


Spanish flu was the most severe and devastating influenza pandemics that the world ever witnessed. Also known as the 1918 influenza pandemic, it infected 500 million people – about a third of the world’s population at the time – in four successive waves.
Though the flu engulfed Europe, America, and parts of Asia, the exact place and cause of its origin are unknown to this day.
Some say that the flu showed itself in the military camp in Kansas, and from the US it spread to Europe when the troops traveled east in World War I.

Though the name is Spanish flu the pandemic did not originate in Spain, the British Medical Journal referred to the virus as “Spanish flu” because Spain was hit hard by the disease.

Small Pox 15th Century:


Smallpox has been estimated to have killed over a 500 million people.
It was in 1980 that the World Health Organization declared smallpox to be eradicated.

Edward Jenner giving the boy smallpox vaccine.
source pic- Smithsonian Magazine

Smallpox became the first death-dealing pandemic whose vaccine was developed in the late 18th-century, by a British doctor named Edward Jenner.

Edward Jenner observed that some local milkmaids were not exposed to the harsh virus and just showed mild symptoms which were called “cowpox”. Edward then decided to extract a small sample of milkmaid’s pus and inject it into the arm of a young boy named James Phipps. After that, he exposed the boy to the smallpox virus, and to his amazement, the boy showed no illness. This was the first vaccine ever discovered in history.

Advantages of multilingualism

Knowing one language is essential human need but learning more than one dialect can bring about new opportunities for any person. Multilingualism not just opens up career opportunities for an individual but also the cognitive benefits of being multilingual are further more than people know. Studies reveal that about 60 to 75 percent of the world population is multilingual. Even certain countries have more than one official language and have made the option to learn a second language mandatory in their school curricula.

Let’s know further the lesser known benefits of multilingualism.

>Sharpens mind

A study at Spain’s Pompeu Fabra University reveals that the effect of a second language acquired later in life can be seen in the growth of brain. While learning a new language sharpens the brain, it also causes the brain to grow and develop proficiency in the first language. Multilinguals have better concentration and observation and analytical skills than monolinguals.

>Improves learning abilities

Memory is a fundamental in learning languages where one gets familiar with not only new vocabulary and rules but also requires the ability to recall the information. The more the use of brain, the better it performs. This enhances one’s learning and memorizing abilities.

>Enhances decision making

Multilingualism leads to flexible and critical thinking and logical reasoning enhancing the decision making ability. Innovative and creative decisions for the betterment of everyone and the society are a part of the improved ability.

>Lessens mental decline in old age

It has been suggested by studies that requirements associated with bilingual or multilingual people act as mental exercise for the brain which may lead to delay in the symptoms of Alzheimer′s disease and other forms of dementia.

>Increases career opportunities

Business companies these days look for individuals of bilingual or multilingual ability considering the diversity of the world. Companies operating in more than one country prefer multilinguistic candidates. Also, tourism and marketing sector provide wide range of opportunities to multi-lingual individuals.

Prophylactic use of antimicrobials – a debatable issue

An ancient and quiet honourable practise has been the use of preventive medicine. For example, the ancient Chinese use to pay their doctors while they remained healthy, however as soon as they felt sick this payment would not be given. The effectiveness of antibiotics as a prophylactic means for protecting healthy individuals exposed to pathogenic bacteria, preventing the development of an infection in chronically ill patients and preventing an infection in patients who undergo surgery is a debatable issue. Many surgeons reported significant reductions in post-operative infection following antibiotic use, and a few did not even reported infections for a period of twenty years. Despite this success, prophylaxis presents certain hazards, including the evolution of antibiotic resistance, superinfections and drug side effects, for the individual patient and for the general public. Therefore, physicians have broad views on the responsible preventive use of antibiotics. However, antimicrobial prophylaxis (AP) should be confined to specific well-accepted evidence for the prevention of excess costs, toxicity and antimicrobial resistance in order to effectively prevent infections. Initial or secondary (recurring prevention or reactivating infections) prophylaxis may also be regarded as primary (prevention of initial infections) or may be administered to prevent infection by killing a colonising organism. Patients should know in detail the potential risks and benefits of AP. The potential risks are allergic reactions with the use of antibacterial agents that can be serious or life-threatening, and clostridium difficile colitis. The risk of tendinitis, including the rupture of the tendon of Achilles should be alerted to patients taking fluoroquinolones.

The pros and cons of using antimicrobials as a prophylactic.

  1. THE PROS: In the diagnosis of life-threatening acute bacterial infections, surgical infectious diseases and if there is an effective use of antimicrobials as prophylaxis, antibiotics can have many benefits.

In bacterial infections: In acute bacterial infections, which were highly mortal before introduction of antibiotics, the benefits of antibiotics as prophylactics is most clearly indicated. Mortality in endocarditis was about 100% prior to 1990 and about 20% total in 2010 although the death rate is usually caused not by unsuccessful antibiotic therapy but by cardiac failure or embolic complications. In bacterial meningitis in 1990, the mortality rate was reduced to 8% to 20% in 2010 and acute osteomyelitis mortality decreased from 50% to less than 1%. Many other infections, in both individual patients and others within the community, have significantly reduced morbidity and serious effects of spraying. In high-risk patients, this included the use of antibiotic prophylaxis for bacterial meningitis. During the systemic inflammatory response (SIR) stage of the infection, the early initiation of broad- spectrum antibiotics was proved critical for preventing the development of sepsis. When appropriate antibiotics are prescribed early in the surgical sepsis, mortality is significantly reduced.

In surgical site infections: Although the technique is still less than good surgical and aseptic technique, the risk of surgical site infection is considerably decreased by antibiotic prophylaxis in high-risk surgical patients such as operations over 2 hours, abdominal procedures, endogenous or exogenous contamination and co-morbidity. The choice of antibiotics depends on the organisms that are most likely to be affected; the kind of operation; the probability of resistance development and the financial cost involved. In felines, the rate of postoperative infections was reduced in the course of the optional orthopaedic surgery by preoperative antibiotic prophylaxis. Therefore, it is usually advisable to treat routine perioperative prophylactic antibiotics, even if numerous orthopaedic operations are categorised as clean. Orthopaedic procedures normally last longer than 90 minutes and the potential infection may be influenced by local wound factors like implants and tissue trauma. In the presence of implants, bone and joint infections are very difficult to treat, increase morbidity and may adversely affect the result. Cefazolin is currently seen as a choice antibiotic because of its outstanding effectiveness, low toxicity and reasonable costs against most surgical wound pathogens. The first dose should be given at a concentration of 22 mg/kg 30–60 minutes before surgery. The dose is usually recommended to be repeated every 90–120 minutes, but there is evidence that the frequency is enough every three hours.

The selection criteria of the antibiotic are:

  • The most prone bacteria that could cause infection should be identified. A prophylactic against frequently found skin bacteria (skin flora) is used when only an incision in the skin is made. An antibiotic is chosen to treat both the skin and the mucosal flora if the mucosal incision is involved.
  • Chemical and drug toxicity characteristics.
  • The least likely antibiotic that is required for serious infections is chosen if different antibiotics are equally helpful for prophylaxis. This helps prevent antibiotic resistance from developing.
  • Sensitivities specific to the environment of the specific hospital. Some hospitals may be very frequent with methicillin-resistant infections, while vancomycin or clindamycin-resistant infections in other hospitals may be more frequent.
  • CONS: The drawbacks of prophylactic antimicrobials are shown by side effects, resistance development and opportunistic pathogens.

Side effects: Their ability to cause serious or fatal adverse reactions sometimes provides a reason to limit the use of antibiotic agents for true therapeutic indications. For example, the most commonly used antibiotics for UTI prevention are nitrofurantoin, trimethoprim/sulfamethoxazole (TMP / SMX), but these drugs have negative reactions in children. Gastrointestinal disturbance, skin reactions such as urticaria, maculopapular rash are the common adverse reactions to nitrofurantoin. Almost exclusively because of sulfamethoxazole, most commonly dermal, adverse events related to trimethoprim/sulfamethoxazole. Serious side effects are extremely rare and mostly reversible when treatment is discontinued but they do exist. The long-term use of low-dose urinary prophylaxis antibiotics is therefore not completely safe. While adverse reactions existed in children to these medications, the lower dose of prevention and the lack of significant co-morbidities and medicinal interactions in children are much less common in children than in adults. In 1% of patients, penicillin causes death from type I anaphylactic shock in sensitive allergic patients and have other harmful consequences. High dose of penicillin may be associated with serum sickness (type III reaction), penicillin, thrombocytopenia, and haemolytic anaemia from cytotoxic antibodies. There is 10 percent cross-sensitivity between the derivatives of penicillin, cephalosporin and carbapenems because they share a similarity between the side chain rather than the beta-lactam structure. Therefore, the same or closely related drug must be avoided to which the patient has shown sensitivity in the past. In certain circumstances, certain drugs are more likely to be toxic. Ampicillin and amoxicillin rash are more common when lymphoid tissue is ebullient, in the case of lymphomas or glandular fever. The following are commonly used antimicrobials for prophylaxis along with their side effects:

  • Penicillin: side effects are reactions of hypersensitivity, renal damage, low potassium (hypokalemia)
  • Cephalosporin: side effects are reactions of hypersensitivity, reduction of blood cell levels such as: neutrophils, leucocytes (leucopoenia) and thrombocytopenia, nausea and vomiting, gastrointestinal problems diarrhoea, anorexia.
  • Metronidazole: side effects are toxicity of the CNS, problems in gastrointestinal tract, neutropenia, blood clotting problems, and alcohol reactions
  • Antibiotic resistant: The bacterial resistance mechanisms are known to include genetic changes, antibiotic metabolism by bacteria, like beta lactamase (beta lactamases), altered receptor site affinity, cell wall permeability alterations (antibiotic efflux pump) and the environmental influence at infection sites. In pus, most bacteria are relatively resistant in the dormant phase. The slow cellular immune mechanism does not affect the intracellular microbes such as tubercle bacillus, Brucella abortus, and Salmonella typhi. This partly explains the slowness of antibiotics in these infections. Infections on heart valves and the meninges, for example, are more resistant to antibiotics than infections elsewhere because the concentrations of polymorphs and macrophages are low. Inappropriate antibiotic treatment facilitates the spread of resistance. In many countries, UTI-associated antibiotic resistance has become widespread. Previous studies showed an increased rate of antibiotic resistance. Antimicrobial resistance in enteric and oropharyngeal flora may be developed through the use of antibiotics for prophylaxis. A recent study has reported a high rate of resistance against third generation cephalosporins in children who received prophylactic antibiotics. Clinicians are advised to carefully use prophylactic antibiotics. Additional hazards are present in antibiotics that inhibit the growth of a range of different types of bacteria. These medications also eliminate benign bacteria that help protect us from diseases by competing with pathogenic bacteria and limiting their propagation. Wide ranging antibiotics may produce deep changes in bacterial population composition and lead to the outgrowth and invasion of so-called superinfections of antibiotic-resistant strains.

Since the V. Cholerae infection dose is high, proper hygiene generally makes immunisation and prophylaxis unnecessary, hence antimicrobial prophylaxis in endemic areas has not proved effective. In the prevention of sexually transmitted diseases, chemical prophylaxis is ineffective. The use of antimicrobials to prevent genital diseases may, indeed, deteriorate the situation by selecting harder resistant strains. Antibiotic products, especially those of a wide activity range, alter the normal flora of the body, allowing resistant and opportunistic pathogens to colonise and multiply. These could cause secondary infections in a healthy female, such as candida vaginitis, or fungal and systemic infection in a highly susceptible patient, such as an immunosuppressive treatment. Clostridium difficile, anaerobic bacterium which can multiply after normal flora is suppressed and is relatively resistant to many commonly employed antibiotics but metronidazole or vanzomycin, causes the severe complication of pseudomembraneous colitis. Between 2000 and 2007, 400 percent of the increased mortality from Clostridium difficile infection was partially due to the emergence of the insusceptible C. fluoroquinolone strain. When pseudomembraneous colitis is developed in transplant patient, it is impaired to absorb the immunosuppressive medications which increase allograft-rejection susceptibility.

Other disadvantages of prophylactic use of antimicrobials are:

  • More expensive treatment: Antibiotics are costly and shouldn’t be used inappropriately. However, the cost of the antibiotics is negligible compared to the cost of hospitalisation for a long stay due to a wound infection in patients at clearly reduced risk of wound infections which were found by prophylaxis. The least cost-effective agent for a short period of time is selected if antibiotic prophylaxis is used.
  • Allergies and toxic reactions: When antibiotics are used, toxic or allergic reactions may occur. These can be reduced for brief periods by using safe agents.
  • The use of antibiotics can lead to a false sense of safety. Careful surgery and precautionary and postoperative care are essential if wound infections are to be minimised.
  • Infection due to side effects by drugs, especially clindamycin, with bacteria such as the Clostridium difficile.

Conclusion:

The use of antimicrobial prophylaxis has led to a large number of infections being prevented and significant declines in surgical infections at the site. Specific, accepted indications should be limited to antimicrobial prophylaxis to avoid excess cost, toxicity and resistance to antimicrobials. The potential risks and benefits of any antimicrobial prophylaxis system should be understood by patients. Although there is evidence based antimicrobial prophylaxis practises, many are based on low evidence or expert advice. Additional antimicrobial prophylaxis studies are necessary. There remain significant controversies in antimicrobial prophylaxis, with many opportunities to practise improvement through rigorous studies. More antibiotics do not always reduce surgical site infection more effectively. There are significant gaps between directives and practises, mainly over the current guidelines on antibiotic prophylaxis.

Unusual jobs we never knew existed

If the usual nine to five jobs sound boring to you, there are a plenty of unusual, interesting and never heard before jobs- jobs which don’t involve in office time at all.

Let’s have a look at the most unusual yet interesting professions.

>Iceberg mover

The idea came up after the tragedy of Titanic in 1912. Professionals and specialists are hired to tow icebergs out of the path of ships and oil rigs. Iceberg movers earn an estimated amount of $19,000 to $52,000 per year.

>Panda nanny

As a part of China Giant Panda Protection, the research centre in China is on hunt for specialised nannies for panda cubs. Those who wish to partake will be provided free meals, transit and accommodations along with an estimated pay of 200,000 Yuan ($32,000) a year.

>Ash artist

We must have heard of sand artists. Ash artist is somewhat similar to it. The only difference being the art piece is made of passed ones’ ashes. Though it might sound creepy but the art made out of the ashes looks beautiful and has a connection since it was made of a person you knew. The estimated pay is $225-$500 per commission.

>Professional mermaid

Though having seen a mermaid for real is not possible but a professional mermaid is definitely a real, though self made, job. There are no schools or institutions providing training in mermaid work. One has to be self motivated and comfortable in practicing and wearing a fish tail like mermaid and swimming like one. Professional mermaid job gets an estimate of $300/hour.

>Professional foreigner

Never thought being a foreign could be a profession? Here is a chance to work as a professional foreigner especially in China. It’s a big business in China where they hire foreigners to attend real estate events and meetings. Professional foreigners earn an approximate of $1,000/week.

>Fortune cookie writer

As the name suggests, those little notes we get in our cookies are usually written by professionals. Companies hire freelancers to make those little slips with sweet messages. Such freelancers get paid $40,000 to $80,000 annually.

Sagrada de Familia: The controversial church

We humans always have an impeccable liking for controversies. They give us something to put the gray cells of our brain to work. Let’s exercise them today by taking a look into the world’s tallest church(basilica), Sagrada de Familia, constructed by the famous architect Antoni Gaudi(1852-1926). The God’s architect, started the construction of Sagrada de Familia in the year 1882. Be prepared for this statement. The basilica is still under construction and will not be completed until 2026! That’s a whooping 135 years of construction! If it is a famous church, which can be funded abundantly, why is it still under construction after over a century?

Sagrada de Familia and its private funding

The construction of the basilica has been carried out with the help of private funding and donations and is not funded by any government or church. Now you may ask why a church has shortage of funds. The answer to this is the beginning of the controversy. Before divulging into it, it is important to note that it isn’t a church, but rather a basilica. It was originally designated as a cathedral but then in 2010, Pope Benedict XVI declared it a basilica. What’s the difference between a basilica and a church?

Antoni Gaudi drew inspiration from nature

Before answering the question of why it is considered controversial, let me give you a brief tour of the basilica. The basilica is to have eighteen spires out of which only eight has been constructed as of now. These spires symbolize the Twelve Apostles, Virgin Mary, Four Evangelists, and Jesus Christ. They also differ in their heights accordingly to denote the hierarchy, with Jesus Christ’s spire the tallest of all at an astounding 560 feet.

Antoni Gaudi was an admirer of nature. He often finds inspiration for his works from mother nature herself.

The great book, always open and which we should make an effort to read, is that of Nature.

-Antoni Gaudi

This can be reflected in his basilica too. To showcase it to you, let me show you a staircase inside the Sagrada Familia. You will notice that the staircase spirals, not ordinarily, but rather ‘scientifically’. The spirals represent the famous Fibonacci spiral. The Fibonacci spiral is a logarithmic spiral whose growth factor is φ, the golden ratio 1.69, which is the ratio which is found almost everywhere. In flowers, sea shells and even the human body. You may now understand Gaudi’s love for nature.

Spiral Staircase
Spiral staircase(Left), a sea shell on the right.

Also, the basilica incorporates curved lines rather than straight ones. This can be observed in the pillars of the basilica, curved and giving the illusion of many trees huddled together to form a forest. According to Gaudi, nature did not give us straight lines. So it is to do justice to nature by incorporating curved lines in his temple.

The straight line belongs to men. The curved one to God.

-Antoni Gaudi

Not only in this basilica, Gaudi’s work reflects nature in many of his other art works and buildings.

Ceiling of Sagrada Familia
Ceiling of Sagrada Familia, resembling trees in a forest

Freemasonist?

magic square
The magic square in the passion façade.

His fascination for nature is co-walked by his fascination for something strange too. Interesting right? Next to the passion façade, near his tomb(yes, Gaudi is buried inside the basilica)there lies a 4×4 magic square with 15 numbers inscribed on it. Even bizarre. These numbers are positioned in such a way that when you add the numbers horizontally, vertically or diagonally, they add up to the number 33!

Now, 33 is not any number. There is symbology in play here. 33 is said to be the highest rank that a freemasonist can go. There exists a controversy that Gaudi was a masonist and that he achieved the 33rd rank. But 33 maybe a coincidence, you may think. But note that his other work Parque Guëll, has staircase whose steps sum to 33 too. Now this is far too real to be ignored as a mere coincidence. One more thing, Gaudi’s friend Eduard was a freemasonist and his patron Guëll was also a freemasonist. These facts make it difficult to ignore ’33’.

Addressing the elephant of the room

So what does all this have to do with the controversy. Gaudi’s nature inspired works were frowned upon during his days. The basilica had undergone many attacks, also a reason for its delayed construction. George Owens, in his novel Homage to Catalonia, wrote:

I went to have a look at the cathedral—a modern cathedral and one of the most hideous buildings in the world. Unlike most of the churches in Barcelona it was not damaged during the revolution—it was spared because of its ‘artistic value,’ people said. I think the Anarchists showed bad taste in not blowing it up when they had the chance.

Alongside this, there was the freemasonist theory. Christianism and freemasonry were not exactly the friendly combo. In 1983, the Church issued a new code of canon law, which stated: ‘A person who joins an association which plots against the Church is to be punished with a just penalty; one who promotes or takes office in such an association is to be punished with an interdict‘.

Such was the heat between these two groups. And having said that Gaudi may have been a masonist, poses no doubt in churches denying funding to Sagrada de Familia. Even though it is addressed a basilica, by now you can be sure that it isn’t seen as one by many Catholics. This can be contradicting and confusing. Like an oxymoron, propagating absolutely different ideas: Science and Religion. These two have always been like oil and water. No matter how hard you try to mix, they will stand separated.

Thus, I leave you all with questions lingering in your minds. May your quest begin!

Note: More information regarding the intertwining of science and religion symbolism can be read in the book ‘Origin’ by Dan Brown. Meanwhile, you can check another article which revolves around the ideas of the book here.

 

 

 

 

Life of a student in Kota | Hostel life in Kota

Life of a student in Kota

Kota is the 2nd largest city located in Rajasthan state in India also known as the hub of education all over India. Many JEE and NEET aspirants each year take admission here, having hopes of getting selected and get admission in IIT, NIT, or AIIMS.

The coaching institutes like Allen, Resonance, Motion, Vibrant, Nucleus and many institutes are popularly known to provide quality education to the students.

I am eligible to talk about life in Kota because I have been there for 2 years and can discuss all the cons and pros of the city.

Hostel life in Kota:

As soon as you take admission to the desired coaching institute, your parents would search for a good hostel. I will be very honest, the price of the hostels is very high to afford. Hostel life, in the beginning, is quite fun but soon you start realizing that people are extremely selfish and will always try to trick you and make you not study. They would study all day and won’t attend you and will start enjoying your quality time of studies. It is on you that how soon you admit that and be aware of such kinds of people. Apart from this hostel life is better in many ways, you get a good circle and if a get a good friend then that will better for you to start your group study.

Coaching schedule in Kota:

The coaching schedule depends on the batch you are mainly it varies from 9 am to 5 pm. Students get adversely affected by the hectic schedule and are always running for marks. Institutes also provide a small canteen for students during break time. In the beginning, you would be allotted a normal batch, and your marks in the future will decide which batch you attain later. The highest qualified batch also called the star batch which is attained only by students who get qualified in the batch shuffling test. These star batch students get better teachers than normal batch students which is quite a hard competition for average students.

Food quality in Kota:

The meal served in hostels is not so good mainly it is simple food which is not liked by most of the students. But don’t worry there are many open messes available and you can pay them if you want to skip your hostel meal. Thursday and Sunday are considered as special meal days in most of the hostels which provide idli, dosa, uttapam, sweet dish and many more.

kotahostel

 

Holidays in Kota:

Students get weekly off from all the classes mainly Sunday, but if a teacher is running out of syllabus, he may schedule an extra class even on Sunday (that is sad). Festival holidays are not given here except Diwali (5-10 days) when all the students run to their homes after long. Raksha Bandhan holiday is also given which is just for 1 day and it is not possible to travel if you belong from a different state.

Distractions in Kota:

I want you to read this part very carefully as I have dealt with how the distraction process goes in Kota. Students here are extremely selfish and would never want to give their a minute to you and if you come between their studies they will make distance from you, this is about studious people. Talking about more than 65% of students in Kota who are involved in many toxic things and mind my words they can distract you as well. The problem is that students get enough freedom in the new city and in the absence of their family they get easily influenced by their friends. Distraction in Kota includes getting into relationships, making friends, or involving with friends who consume drugs, alcohol, and whatnot. What you need to realize is to stay away from these types of friends and make some quality friends who take their studies seriously.

All the best students who are going to Kota for their studies always be confident, stay in touch with your family and share every problem that arises before you. Remember parents sent you with hopes and they will help you in every possible way.

Hope it helps!

Being introvert

An introvert is often thought of as a shy, quiet, calm and reserved individual having minimal social interactions. Social engagements and special attention are not what an introvert looks for. Instead, introverts find more comfort in solitude and focusing on inner thoughts and ideas. Investing more of their time in reading, writing, creativity, music and art is what energises them. Social gatherings might not be their interest but alone time is what they prefer most.

Following these traits introverts are often misunderstood.

Misconception no.1: Introverts are shy

Being shy is not the same as being introvert. Introverts enjoy solitude and tend to be reserved and prefer being alone or in small groups. This is often mistaken as being shy.

Misconception no.2: Introverts are rude

Introverts value their privacy and don’t believe much in expressing their emotions publicly. This tends people to dislike them and mistake them for being rude or weird at times.

Misconception no.3: Introverts are boring

Socializing in gatherings and parties and hanging out with peers might not be their kind of thing but that doesn’t make introverts boring. Time spent with inner circle of friends and family in a low key environment is more valuable for them.

Misconception no.4: Introverts can’t make friends

Introverts need their time to open up to new relationship. When it comes to befriending someone, introverts choose to have close friends, though less in number. They prefer smaller circle and high quality relationships.

Misconception no.5: Introverts are underconfident

Our society equates confidence with boldness, strong statements and actions directed externally which come naturally to extroverts. On the other hand, introverts don’t believe in the public display of confidence. Even though they feel confident inside, they don’t show much of it on the outside. Keeping emotions to themselves is natural in introverts.

Misconception no.6: Introverts are emotionless

Keeping emotions to themselves is natural in introverts. They have great control on their emotions and avoid expressing the same publicly. Though introverts might not seem to be emotionally engaged but usually that’s not the case.

Misconception no.7: Introverts wish to be extroverts

Sometimes, introverts might envy the abilities of extroverts to fit quickly and naturally to any social environment. But they do take great joy in being themselves and the delight of being in their own inner world. Being introvert is a gift where one enjoys equally self company and the company of others and wishing to be someone else is not the desire.

Misconception no.8: Introverts can turn into extroverts some day

Introversion is a personality trait which can either degrade or upgrade but never change. It is similar to wine which will only get better with aging but never change into something else i.e. one can grow up to be a mature introvert but not an extrovert.

We live in a fast growing world where chatty behaving individuals are preferred over the quite listeners. Many introverts find it difficult making their way through this scenario. However, introversion must be observed as a gift- a gift of thoughtfulness, compassion and creativity. Introverts are considerate, compassionate, deep thinkers, natural writers, problem solvers, keen observers, good listeners and readers- everything the world needs today.